-women of childbearing age

-join problems

-butterfly rash

-Raynaud

-serosal: pericarditis, pleuritis

-diffuse interstitial pulmonary fibrosis: interstitial pneumonitis, diffuse fibrosing alveolitis

-verrucous endocarditis – affects mitral valves on both sides

-vasculitis – onion skin appearnce (concentric rings of collagen)

-Glomerular changes

            -immune complex deposition: subendothelial (wireloop), mesangial

            -endothelial proliferation

            -thickening basement memberane

-Diagnosis: LE cells, dsDNA, Sm antigen, decreased serum complement, immun complexes at dermal-epidermal junction, false-positive test for syphilis (due to cardiolipin)